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热损伤可导致机体正常免疫系统的一系列变化,免疫缺陷往往导致创面脓毒症等并发症的发生,甚至死亡。多形核中性白细胞(PMNs)在宿主对抗原刺激的非特异性免疫反应和炎症反应中起着重要的作用。当PMNs吞噬了微生物后,在PMNs内便立即发生一系列反应,首先发生暴发性氧耗,氧化产生H_2O_2,并进而产生OH~-等氧自由基。这些物质均是重要的杀菌介质。烧伤后PMN_s的趋化、吞噬和杀菌功能均遭损害。检测PMN_s杀菌能力的主要方法是化学发光法,或者测定其在氧化代谢过程
Thermal damage can lead to a series of changes in the body’s normal immune system, which often leads to complications such as wound sepsis and even death. Polymorphonuclear neutrophils (PMNs) play an important role in the host’s non-specific immune response and inflammatory response to antigen stimulation. When PMNs phagocytose the microorganisms, a series of reactions take place immediately within the PMNs. First, the outbreak of oxygen consumption occurs, and H 2 O 2 is oxidized to generate OH ~ - and other oxygen free radicals. These substances are important sterilization medium. Chemotaxis, phagocytosis and bactericidal activity of PMN_s after burn were both impaired. The main method to detect the bactericidal activity of PMN_s is chemiluminescence, or to determine its effect on oxidative metabolism