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L-乙酰肉毒碱(AcCn)是肉毒碱的O-乙酰衍生物(γ-氨基羟基丁酸的三甲基铵乙内酯).肉毒碱及其衍生物的作用机制是在细胞尤其是骨骼肌和心肌的中间代谢中,作为脂肪酸的线粒体载体进行胞体浆的转乙酰作用.AcCn对CNS有多种生化和药理作用.Falchetto通过微电解质透入法将AcCn注入猫的单神经细胞中,初步证实AcCn有拟乙酰胆碱(ACh)效应.这与AcCn和ACh之间结构类似及间接影响胆碱能神经突触对ACh的释放有关.另外AcCn在5-HT神经突触上的作用引人注目.在许多类型忧郁症,特别是老年人的发病机制中,5-HT起着重要的作用.AcCn影响5-HT神经突触的功能,因而具有治疗意义.
Acetylcarnitine (AcCn) is a carnitine O-acetyl derivative (trimethylammonium lactone of gamma-aminohydroxybutyrate) .The mechanism of action of carnitine and its derivatives is that in the cells, especially Is the transmethylation of cell plasma pulp as a fatty acid mitochondrial carrier in the intermediate metabolism of skeletal and cardiac muscle.AcCn has a variety of biochemical and pharmacological effects on CNS.Falchetto injects AcCn into mononeurons of the cat by microelectrolyte penetration , Initially confirmed AcCn has acetylcholine (ACh) effect.This is AcCn and ACh structure similar and indirectly affect cholinergic synapses ACh release on the other AcCn 5-HT synapses in the introduction of the role of Attention is focused on the role of 5-HT in the pathogenesis of many types of depression, especially in older adults, and AcCn has therapeutic implications for the function of 5-HT neuronal synapses.