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目的:观察咽舒饮泡腾片的急性毒性反应及其抗炎抗菌药效,为临床用药和进一步的开发研究提供理论依据。方法:咽舒饮泡腾片以最大浓度最大剂量灌胃,连续7 d观察小鼠急性毒性反应情况:采用二甲苯致小鼠耳廓肿胀,小鼠棉球肉芽肿实验观察咽舒饮泡腾片的抗炎作用;观察咽舒饮泡腾片对5种较常见易感菌的抑菌和杀菌情况。结果:咽舒饮泡腾片最大浓度、最大剂量灌胃后动物表现有活动减少,摄食减少,稀便甚至腹泻,但2～3d后均恢复正常,7 d后全部动物健存,体重情况与正常组无明显区别,未见其它任何毒副反应;咽舒饮泡腾片可明显抑制二甲苯所致小鼠耳廓肿胀和棉球肉芽肿组织增生,具有广谱抑菌作用并对乙型溶血性链球菌显示出非常良好的抑菌作用和杀菌活性。结论:咽舒饮泡腾片的急性毒性低,具有较好的抗炎和抑菌杀菌药理作用,对治疗咽炎有良好的效果。
Objective: To observe the acute toxicity of Yanshuyin Effervescent Tablets and its anti-inflammation and antibacterial efficacy, and to provide theoretical basis for clinical drug use and further development and research. Methods: Dangshuyin Effervescent Tablets were intragastrically administered at the maximum concentration. The acute toxicity of mice was observed continuously for 7 days. The mice were swollen with xylene and the mice were swollen by granuloma. The anti-inflammatory effect of the tablet; Observation of the antibacterial and bactericidal effects of Yanshuyin Effervescent Tablets on the five most common susceptible bacteria. Results: The maximum concentration and maximum dose of Yanshuyin Effervescent Tablets showed decreased activity, reduced feeding, loose stools, and even diarrhea after gavage, but returned to normal after 2 to 3 days. All animals survived after 7 days and their weight was There was no significant difference in the normal group, and no other toxic side effects were seen; Yanshuyin effervescent tablet could significantly inhibit xylene-induced mouse ear swelling and cotton ball granulomatous tissue proliferation, with broad spectrum antibacterial effect and type B Hemolytic streptococci show very good bacteriostatic and bactericidal activity. Conclusion: Dangshuyin Effervescent Tablets have low acute toxicity, good anti-inflammatory and anti-microbial bactericidal effects, and have a good effect on the treatment of pharyngitis.