论文部分内容阅读
目的探讨高原移居者和世居者对低氧和高氧的通气反应性。方法对５名从平原移居海拔４７５０ｍ２０天～８０天的汉族（Ⅰ组）、１６名从平原移居该高原３年～２０年的汉族（Ⅱ组）和５名当地世居藏族（Ⅲ组）受试者做了呼吸空气、进行性低氧和１００％氧的通气反应测定，以ＶＥ／Ｓａ０２（Ｌｍｉｎ－１）表示通气反应大小。结果呼吸空气时，Ⅰ组ＶＥ／Ｓａ０２值（０．１８±０．１４）明显高于Ⅱ组（０．１３±０．０３）和Ⅲ组（０．１３±０．０３），Ｐ＜０．０５，Ⅱ、Ⅲ组间无显著性差异。进行性低氧１ｍｉｎ、２ｍｉｎ和３ｍｉｎ，Ⅰ组ＶＥ／Ｓａ０２值（分别为０．２０±０．０４、０．２７±０．０４和０．５６±０．０７）明显高于Ⅱ组（０．１４±０．０４、０．２０±０．０４和０．３４±０．０５）和Ⅲ组（０．１３±０．０２、０．１５±０．０３和０．２２±０．０４），Ｐ＜０．０５，Ⅱ、Ⅲ组间第１ｍｉｎ和第２ｍｉｎ无显著性差异，第３ｍｉｎ有显著性差异（Ｐ＜０．０５）。三组吸入１００％氧时，通气量均明显降低。结论平原人移居高原初期，低氧通气反应敏感，而久居和世居高原者则迟钝。三组吸高氧时，通气均被抑制。
Objective To investigate the ventilatory reactivity of plateau migrants and inhabitants to hypoxia and hyperoxia. Methods Five Han Chinese (Group Ⅱ) and five local native Tibetans (Group Ⅲ) who migrated from plain to 4750m 20 days to 80 days at sea level (Group Ⅰ), 16 migrated from plain to plateau for three years to 20 years The subjects did air breathing, progressive hypoxia and ventilation with 100% oxygen. The ventilation response was expressed as VE / Sa02 (Lmin-1). Results Compared with group Ⅱ (0.13 ± 0.03) and group Ⅲ (0.13 ± 0.03), the value of VE / Sa02 in group Ⅰ (0.18 ± 0.14) .05, Ⅱ, Ⅲ no significant difference between groups. The values of VE / Sa02 in group Ⅰ (0.20 ± 0.04, 0.27 ± 0.04 and 0.56 ± 0.07, respectively) were significantly higher than those in group Ⅱ .14 ± 0.04, 0.20 ± 0.04 and 0.34 ± 0.05) and group Ⅲ (0.13 ± 0.02, 0.15 ± 0.03 and 0.22 ± 0.04 ), P <0.05. There was no significant difference between the 1st and 2nd minutes in group Ⅱ and Ⅲ, and there was a significant difference at the 3rd minute (P <0.05). Three groups inhaled 100% oxygen, the ventilation were significantly reduced. Conclusion During the initial stage of plateau migration to the plateau, hypoxia ventilation was sensitive, while those living in the plateau and the plateau were slow. Ventilation was inhibited in all three groups when hyperoxia.