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作者研究不同潮气涨落幅度对RDS肺的作用.受试动物按潮气涨落的大小,依次分为A,B,C 3组.从气体交换、肺力学及组织病理学等方面进行考察、当吸入纯氧时,各组Pao,均大于53.3kPa,唯A组有CO_2潴留,通气2h时,A,B组的P-V环接近于正常,C组出现拐点和明显的迟滞现象.肺的湿重/T重比在A,B,C 3组依次增大,A和C组差异显著(P<0.05).C组肺损伤较为严重,通气4 h形成透明膜.上述结果提示,过大的潮气涨落使肺在通气过程中进一步受累.减少周期性波动幅度对肺有一定保护作用.
The authors studied the effect of different tidal fluctuations on the RDS lungs.The animals were divided into groups A, B, and C according to the size of the tidal fluctuations, including gas exchange, lung mechanics and histopathology, etc. When When pure oxygen was inhaled, the Pao in each group was greater than 53.3 kPa, and the retention of CO_2 was the only in group A. After 2 hours of ventilation, the PV rings in groups A and B were close to normal, and inflexion and obvious hysteresis occurred in group C. The wet weight / T weight ratio in the A, B, C group increased in turn, A and C group significant difference (P <0.05) .C group of lung injury is more serious, ventilation for 4 h to form a transparent membrane.The above results suggest that excessive moisture Fluctuations make the lung further involvement in the ventilation process to reduce the cyclical fluctuations in the lung have a protective effect.