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王月娥等报道,饲料中若含5%棉子粉,5周后大鼠附睾尾内均为死精子;然而给兔连续喂饲含10%棉子粉的饲料,历时9周,对精子活力仍无影响。张明觉等报道,雄兔服1.25—10毫克/公斤的醋酸棉酚,每周5次,历时5—14周,精子发生依然正常;但大鼠与仓鼠服棉酚5或10毫克/公斤,12周后,即出现死精和不正常的精子。本实验室曾以10毫克/公斤/天剂量的棉酚给大鼠灌服,每周6次,5周后附睾尾内全为死精;而以20毫克/公斤/天的棉酚灌服小鼠,历时60天,亦未见附睾尾内有死精子出现。Nieschlag认为,大鼠、仓鼠、猴和人对棉酚敏感,而小鼠、豚鼠、兔、猪、山羊、绵羊和牛则不然。棉酚抑精作用为何有如此明显的种属差异?为了探讨其
Wang Yue-e and other reports, if the feed contains 5% cottonseed powder, 5 weeks after the rat epididymis tail are dead sperm; however, rabbits fed a continuous feed containing 10% cottonseed powder, which lasted 9 weeks on sperm motility is still no effect. Zhang Mingjue and other reports, male rabbits serving 1.25-10 mg / kg of gossypol acetate, 5 times a week lasted 5-14 weeks, spermatogenesis is still normal; but rats and hamsters gossypol 5 or 10 mg / kg, 12 Weeks, there are dead and abnormal sperm. In our laboratory, the rats were dosed with gossypol at a dose of 10 mg / kg / day six times a week for 5 weeks. Mice, which lasted 60 days, no dead spermatozoa appeared in the epididymal tail. Nieschlag believes that rats, hamsters, monkeys and humans are sensitive to gossypol, while mice, guinea pigs, rabbits, pigs, goats, sheep and cattle are not. Why gossypol so significant differences in species? To explore its