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目的为阐明脊髓内的α肾上腺素能受体对心血管活动调节的作用。方法在完整和颈1横断脊髓的大鼠，脊髓蛛网膜下腔注射（ith）选择性α1受体激动剂去氧肾上腺素后对血压和心率进行观察记录。结果①完整大鼠ith去氧肾上腺素引起血压和心率明显升高。②在颈1横断脊髓的大鼠，ith相同剂量的去氧肾上腺素也引起显著的升高血压效应。③在颈1横断脊髓的大鼠，ithα受体阻断剂妥拉苏林可减弱ith去氧肾上腺素的升压效应；用选择性α1受体阻断剂哌唑嗪预处理能阻断这种升压效应。结论在脊髓水平存在有由α1受体调控的升压机制。
Aim To elucidate the role of alpha adrenergic receptors in the spinal cord in regulating cardiovascular activity. Methods Blood pressure and heart rate were recorded and recorded after intact and cervical 1 transected spinal cord in rats and spinal subarachnoid (ith) selective α1 receptor agonist phenylephrine. Results ① intact rat ith phenylephrine caused a significant increase in blood pressure and heart rate. ② In the cervical 1 transected spinal cord rats, ith same dose of phenylephrine also caused a significant increase in blood pressure effect. ③ In the cervical 1 transected spinal cord in rats, ithα receptor blocker torathulin can reduce ith phenylephrine boost effect; with selective α1 receptor blocker prazosin pretreatment can block this Boost effect. Conclusions There is a mechanism of voltage regulation by the α1 receptor at spinal level.