论文部分内容阅读
［目的］ 探索有机镓化合物对视觉神经传导道路的功能影响。［方法］ 取白色家兔１２ 只，分１０、１５、２０ｍ ｇ／ｋｇ 三个致死量组，用２－二甲氨基环己氧基－二甲基镓（ＤＤＧ）一次性灌胃染毒，分别于染毒前、染毒后２４ｈ 及４８ｈ，对各组家兔测定视皮层诱发电位（ＶＥＰ）和视网膜电位（ＥＰＧ）。［结果］ １２只家兔中出现精神抑制症状严重的７ 只中毒家兔，均于染毒后２４ｈ 出现ＶＥＰ异常，表现为Ｂ波电位降低，Ｂ／Ａ比值减小。对其中４ 只家兔测定了ＥＲＧ，表现为ｂ 波电位降低，ｂ／ａ比值也减小。在存活动物中，随着中毒症状的恢复，上述二项指标均于４８～７２ｈ逐渐恢复至正常水平。［结论］ ＤＤＧ引起的视觉异常可能是视皮层功能抑制所致，是可逆的。
[Objective] To explore the functional effect of organic gallium compounds on the path of optic nerve conduction. [Method] Twelve white rabbits were divided into three lethal dose groups (10, 15 and 20 m g / kg) and treated with 2-dimethylaminocyclohexyloxy-dimethylgallium (DDG) Visual evoked potential (VEP) and retinal potential (EPG) were measured in all rabbits before exposure and at 24h and 48h after exposure. [Results] Seven rabbits with severe depressive symptoms were found to have VEP abnormalities at 24h after exposure. The B wave potential decreased and B / A ratio decreased. In 4 of them, ERG was measured, showing a decrease in b wave potential and a decrease in b / a ratio. In the survival of animals, with the recovery of symptoms of poisoning, the above two indicators were gradually returned to normal levels 48 ~ 72h. [Conclusion] Visual abnormalities caused by DDG may be caused by inhibition of visual cortex function and are reversible.