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[目的]了解广西健康人群中W135群脑脊髓膜炎的免疫水平和带菌情况,为预防控制该病提供科学依据。[方法]在广西梧州、来宾和全州按年龄分层随机抽样调查0～82岁人群344人,采集咽拭子进行脑膜炎奈瑟菌培养,采集血清标本用ELISA法检测W135群脑膜炎球菌多糖抗体IgG含量,以抗体浓度≥2μg/ml者为阳性。[结果]调查对象中未检出W135群带菌者。抗体阳性率为6.69%,阳性者抗体几何平均浓度(GMC)为3.88μg/ml。梧州标准化率(12.54%)高于来宾(4.46%)和全州(2.23%)(分别为P=0.0183和P=0.0117)。抗体阳性率在0、1～、5～、10～、15～、20～、30～、40～岁组分别为7.14%、0%、2.38%、2.63%、6.82%、23.53%、15.22%、9.43%,﹤20岁人群(3.07%)低于≥20岁(13.79%)(P=0.0002);阳性率在性别间、阳性者GMC在地区间和年龄组间差异均无统计学意义。[结论]广西存在流脑W135群感染并有地区差异,感染从儿童时期开始,高峰在20～29岁;人群对之有很高易感性,尤其是儿童。
[Objective] To understand the immune status and carriage of W135 meningococcal meningitis in healthy population of Guangxi, and provide a scientific basis for the prevention and control of the disease. [Methods] A total of 344 persons aged 0-82 years were randomly sampled from different age strata in Wuzhou, Guangxi Province. The throat swabs were collected for the culture of Neisseria meningitides. Serum samples were collected to detect the serogroups of W135 meningococci IgG content of antibody to antibody concentration ≥ 2μg / ml were positive. [Results] W135 carriers were not detected in the surveyed subjects. The antibody positive rate was 6.69%, and the positive antibody geometric mean concentration (GMC) was 3.88μg / ml. The standardization rate of Wuzhou (12.54%) was higher than that of guests (4.46%) and the state (2.23%) (P = 0.0183 and P = 0.0117, respectively). The positive rate of antibody was 7.14%, 0%, 2.38%, 2.63%, 6.82%, 23.53% and 15.22% respectively in 0,1 ~, 5 ~, 10 ~, 15 ~, 20 ~, 30 ~ , 9.43%, <20 years old (3.07%) were less than ≥20 years old (13.79%) (P = 0.0002). There was no significant difference in gender and gender between GMCs in different regions and age groups. [Conclusion] Guangxi has the infection of meningitis group W135 with regional differences. The infection starts from childhood and the peak is between 20 and 29 years old. The population is highly susceptible to it, especially to children.