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许多癌症治疗会破坏女性的生殖器官,引起卵巢不可逆损伤。目前癌症治疗的方法有保守外科、化学疗法和放射疗法。化学疗法可诱发急性卵泡损伤,减少卵泡数目,从而使卵泡闭锁。烷化剂如环磷酰胺的最常见的副作用是破坏卵母细胞和颗粒细胞,青少年用烷化剂治疗癌症可使卵巢早衰(POF)的危险性提高4倍。
Many cancer treatments can destroy a woman’s reproductive organs, causing irreversible damage to the ovary. The current methods of cancer treatment are conservative surgery, chemotherapy and radiation therapy. Chemotherapy can induce acute follicular damage, reducing the number of follicles, so that follicles atresia. The most common side effect of alkylating agents, such as cyclophosphamide, is the destruction of oocytes and granulosa cells, and adolescent treatment of cancer with alkylating agents can increase the risk of premature ovarian failure (POF) by a factor of four.