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目的:探讨HPV检测、液基细胞学及阴道镜下组织活检在宫颈病变普查中的应用价值。方法:2010年1月～2011年12月对接受宫颈病变普查的已婚妇女进行HPV检测,并对其中HPV阳性的患者进行液基细胞学及阴道镜下组织活检。结果:液基细胞学诊断与以组织病理学结果进行比较,HPV阳性患者细胞学LSIL阳性率为66.67%(104/156),组织学CIN I以上阳性率为72.44%(113/156)。两种检查诊断方法的符合率比较有统计学差异(χ2=1.23,P<0.05)。不同年龄组患者的患病率明显不同,CIN主要集中在31～40岁生育及性活跃年龄段。从患者的病变程度来看,只有HPV感染而未发展成为CIN者居多,其次是CINⅠ。结论:液基细胞学和阴道镜检查是两个互补的检查项目,液基细胞学检查辅以HPV检测及阴道镜下活检可以大大提高宫颈病变的诊断率。
Objective: To investigate the value of HPV detection, liquid-based cytology and colposcopic biopsy in the screening of cervical lesions. Methods: From January 2010 to December 2011, HPV tests were performed on married women undergoing cervical disease screening and liquid-based cytology and colposcopic biopsy were performed on those with HPV positive. Results: Compared with histopathological results, the positive rate of LSIL in HPV-positive patients was 66.67% (104/156), and the positive rate of histological CIN I was 72.44% (113/156). The coincidence rates of the two diagnostic tests were statistically significant (χ2 = 1.23, P <0.05). The prevalence of different age groups was significantly different, CIN mainly in the 31 to 40-year-old fertility and sexual active age. From the degree of patient’s disease point of view, only HPV infection and did not develop into CIN are mostly followed by CIN Ⅰ. Conclusion: Liquid-based cytology and colposcopy are two complementary items. Liquid-based cytology combined with HPV test and colposcopy biopsy can greatly improve the diagnosis rate of cervical lesions.