首次以固载杂多酸盐 Ti Si W12 O4 0 / Ti O2 为多相催化剂 ,通过正丁酸和正丙醇反应合成了丁酸正丙酯 ,并探讨了诸因素对酯化率的影响。实验表明 :Ti Si W12 O4 0 / Ti O2 具有良好的催化活性 ,醇酸物质量之比为 1 .4∶ 1 ,催化剂用量为反应物料总量的 2 .0 % ,反应时间 2 .0 h,反应温度 1 0 6～ 1 1 2℃ ,酯化率可达 98.3 %。 For the first time, n-propyl butyrate was synthesized from n-butyric acid and n-propanol by immobilizing heteropoly acid salt Ti Si W12 O4 0 / Ti O2 as heterogeneous catalyst. The effects of various factors on the esterification rate were also discussed. The experimental results show that Ti Si W12 O4 0 / Ti O2 has good catalytic activity, the molar ratio of alkoxides is 1.4: 1, the amount of catalyst is 2.0% of the total amount of reaction materials, the reaction time is 2.0 h, The reaction temperature is 1 0 6 ~ 1 1 2 ℃, the esterification rate can reach 98.3%.