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目的研究盐酸米诺环素联合替硝唑治疗慢性牙周炎的疗效,为慢性牙周炎的治疗提供依据。方法 80例患者随机均分为对照组和联合用药组,对照组局部使用盐酸米诺环素软膏治疗,联合用药组在此基础上口服替硝唑进行治疗,治疗期为4周。检测2组患者治疗前后的全口牙菌斑指数(PLI)、牙周附着水平(PAL)、牙周探诊深度(PPD)、牙齿松动度(MD)和牙龈指数(GI),并评价疗效。结果 2组患者在治疗后牙周炎相关指标均较治疗前明显改善,差异均有统计学意义(P<0.05)。但2组患者相关指标治疗后的差异均无统计学意义(P>0.05)。对照组和联合用药组的总有效率分别为97.8%和98.9%,差异均无统计学意义(P>0.05);显效率分别为61.1%和87.8%,差异有统计学意义(P<0.05)。结论盐酸米诺环素联合替硝唑治疗慢性牙周炎疗效确切。
Objective To study the curative effect of minocycline combined with tinidazole in the treatment of chronic periodontitis and provide the basis for the treatment of chronic periodontitis. Methods Eighty patients were randomly divided into control group and combination group. The control group was treated locally with minocycline hydrochloride ointment. The combination group was treated with tinidazole orally for 4 weeks. The plaque index (PLI), periodontal attachment (PAL), periodontal exploration depth (PPD), tooth mobility (MD) and gingival index (GI) were measured before and after treatment in two groups, and the therapeutic effect . Results After treatment, the related indicators of periodontitis were significantly improved in both groups (P <0.05). However, there was no significant difference between the two groups after treatment (P> 0.05). The total effective rates of the control group and the combination group were 97.8% and 98.9%, respectively, with no significant difference (P> 0.05); the effective rates were 61.1% and 87.8% respectively, with statistical significance (P <0.05) . Conclusion Minocycline hydrochloride combined with tinidazole is effective in treating chronic periodontitis.