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为研究饲养室空气环境对大鼠卡氏肺孢子虫肺炎（ Ｐ Ｃ Ｐ）诱导率的影响，将雄性清洁级 Ｓ Ｄ 大鼠随机分成两组，分别置于普通级饲养室（普通空气组，ｎ＝ ５４）及清洁级垂直层流室（清洁空气组，ｎ＝ ５０），均每周２ 次皮下注射醋酸可的松２５ｍ ｇ／只，连续１２ 周，然后做肺组织印片及支气管肺泡灌洗液沉渣涂片， Ｇｉｅｍ ｓａ 染色后镜检，并做肺组织切片， Ｇｒｏｃｏｔｔ Ｇｏｍ ｏｒｉ银染后检测卡氏肺孢子虫（ Ｐ Ｃ），确定 Ｐ Ｃ Ｐ诱导率。结果显示，清洁空气组 Ｐ Ｃ Ｐ诱导率为２８％ （１４／５０），明显高于普通空气组（０％ ，０／５４， Ｐ＜ ０．００１）。而普通空气组细菌性肺炎的发生率（８９％ ，４８／５４）明显高于清洁空气组（６２％ ，３１／５０， Ｐ＜ ０．０１）。提示饲养室空气环境可 Ｐ Ｃ Ｐ的诱导率。
In order to study the influence of air environment in rearing room on the induction rate of Pneumocystis carinii pneumonia (P C P) in rats, male clean S D rats were randomly divided into two groups and placed in ordinary feeding room (normal air group, (n = 54) and clean-level vertical laminar flow room (clean air group, n = 50) were subcutaneously injected with corticosterone 25 g twice a week for 12 consecutive weeks and then lung tissue print and bronchoalveolar Lavage sediment smear, Giem sa staining microscopy and lung tissue sections, Grocott Gom ori silver staining after detection of Pneumocystis carinii (P C), to determine the P C P induction rate. The results showed that the induction rate of P C P in the clean air group was 28% (14/50), which was significantly higher than that in the normal air group (0%, 0/54, P <0.001). The incidence of bacterial pneumonia in the common air group (89%, 48/54) was significantly higher than that in the clean air group (62%, 31/50, P <0.01). Prompt room air environment can P C P induction rate.