盐酸普鲁卡因注射液是临床上常用的局麻药,其含量测定目前多采用亚硝酸钠法,但由于操作繁琐,终点不易判断,测定结果不理想本文在注射液中的水解产物——对氨基苯甲酸符合药典规定限量的条件下,根据盐酸普鲁卡因能与对二甲氨基苯甲醛缩合成 Schiff 碱的原理,用分光光度法测定盐酸普鲁卡因含量,效果较好。现介绍如下:1.标准溶液的配制:精取在105℃干燥至恒重 Procaine hydrochloride injection is clinically used local anesthetic, the content of sodium nitrite method currently used more, but because of cumbersome operation, the end point is not easy to judge, the determination result is not ideal in this article in the injection of hydrolyzate - Aminobenzoic acid in line with the provisions of the pharmacopoeia under the conditions of the procaine hydrochloride and p-dimethylaminobenzaldehyde condensation into Schiff base principle, spectrophotometric determination of procaine hydrochloride content, the effect is better. Are introduced as follows: 1. Preparation of standard solution: Extract at 105 ℃ drying to constant weight