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首次发现抗过敏药物酮替芬及其同类药物赛庚啶、苯噻啶对约氏疟原虫及伯氏疟原虫高度抗氯喹株均具有杀灭作用。酮替芬0.8mg/d×4及赛庚啶0.6 mg/d×4在抑制及治疗试验中均可使小鼠治愈,并不再复燃,但苯噻啶8mg/d×4则只能在抑制试验中使小鼠痊愈。初步讨论了它们的化学结构与抗疟效果的关系。
For the first time, it was found that the antihyperinfective drug ketotifen and its homologous drugs cyproheptadine and phenylthiazidine have a killing effect on Plasmodium yoelii and Plasmodium berghei highly chloroquine resistant strains. Ketotifen 0.8 mg / d × 4 and cyproheptadine 0.6 mg / d × 4 in the inhibition and treatment trials mice can be cured, and does not relapse, but Pizhiridine 8mg / d × 4 can only Mice were healed in an inhibition test. Preliminary discussion of their chemical structure and anti-malarial effect.