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根据口服糖耐量试验将 3 4例沈阳地区研究对象分为正常糖耐量 (NGT)组、新生腹血糖受损 (新IFG)组、新糖耐量减低 (新IGT)组和旧糖耐量减低 (旧IGT)组。运用高胰岛素正葡萄糖钳夹技术测定胰岛素抵抗程度 ,用静脉葡萄糖刺激胰岛素释放试验测定胰岛素一相分泌量和二相分泌量。结果 :胰岛素钳夹试验 :NGT、新IFG、新IGT、旧IGT组的葡萄糖输注速率 (GIR ,mg/kg/min)分别为 1 0 2± 0 9;6 0± 0 9;5 8± 0 7;44± 0 3。新IFG、新IGT、旧IGT组均比NGT组显著减低 (P <0 0 0 1 ;P <0 0 0 1 ;P <0 0 0 1 )。胰岛 β细胞功能 :①胰岛素—相分泌量 (mU/l) :新IFG、新IGT、旧IGT组分别为 2 2 0± 61 ;3 3 1± 89;1 1 5± 1 8;与NGT组 ( 2 2 1± 2 7)相比 ,新IFG和NGT组处于同一水平 ,但新IGT有高于NGT组的趋势 ,而旧IGT组有降低趋势但无统计学差异 (P >0 0 5 )。②胰岛素二相分泌量 (mU/l) :NGT、新IFG、新IGT、旧IGT组分别为 88± 7;1 1 0± 1 9;2 2 0± 80 ;1 2 2± 7,新IGT组明显高于其它三组 (P <0 0 1 ;P <0 0 5 ;P <0 0 5 )。结论 :新旧空腹血糖切点划分出的IGR均出现了胰岛素抵抗 ,胰岛素的分泌模式也和NGT有了差异
According to the oral glucose tolerance test, 34 subjects in Shenyang were divided into normal glucose tolerance (NGT) group, neonatal impaired glucose tolerance (IFG) group, new impaired glucose tolerance (IGT) group and old impaired glucose tolerance IGT) group. Insulin resistance was measured by using hyperinsulinemic positive glucose clamp technique. Insulin release assay was used to measure the amount of insulin one phase and two phase secretions. RESULTS: Insulin clamp test showed that glucose infusion rate (GIR, mg / kg / min) of NGT, new IFG, new IGT and old IGT group were respectively 102 ± 0 9, 60 ± 0 9 and 58 ± 5 0 7; 44 ± 0 3. New IFG, new IGT, old IGT group were significantly lower than those of NGT group (P <0.01 1; P <0.01 1; P <0.01 1). Islet β-cell function: ① Insulin-phase secretion (mU / l): The new IFG, new IGT, old IGT group were respectively 220 ± 61, 3 3 ± 89 and 115 ± 1 8; (2 2 1 ± 2 7), the new IFG and NGT group were at the same level, but the new IGT group had higher tendency than the NGT group, while the old IGT group had the tendency of decreasing but no significant difference (P> 0.05) . ② The amount of two-phase insulin secretion (mU / l): NGT, new IFG, new IGT and old IGT were 88 ± 7, 110 ± 1 9, 220 ± 80, 122 ± 7, Group was significantly higher than the other three groups (P <0.01; P <0 05; P <0 05). CONCLUSION: Insulin resistance is found in IGR divided by new and old fasting plasma glucose, and insulin secretion pattern also differs from NGT