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作者报告1例糖尿病患者因长期服甲磺丁脲引起二肺弥漫性病变。患者59岁,男,患轻度糖尿病,胸片正常。应用甲磺丁脲每日1克治疗,18个月后发生上呼吸道感染,持续2周,胸部X线检查发现二肺弥漫性斑片状阴影。患者有吸烟史,但无咳嗽、盗汗及咯血史。实验室检查:白细胞8,000～11,000,嗜酸性粒细胞7～8％。痰化脓菌、结核菌和真菌检查,冷凝集试验均阴性;几种真菌病皮肤试验和补体结合试验均阴性。反复胸片检查,肺部斑状浸润持续存在。因此高度怀疑系甲磺丁脲引起的过敏反应,乃停药,3周内肺部弥漫性病变几乎完全消散。
The authors report a case of diabetes mellitus caused by chronic long-term diffuse lung lesions. 59-year-old male, suffering from mild diabetes, normal chest X-ray. Metoclopramide 1 g daily treatment, 18 months after the upper respiratory tract infection, lasted 2 weeks, chest X-ray examination found diffuse pulmonary patchy shadow. The patient had a history of smoking but no history of cough, night sweats and hemoptysis. Laboratory tests: leukocytes 8,000 to 11,000, eosinophils 7 to 8%. Sputum pyogenic bacteria, mycobacteria and fungi examination, cold agglutination test were negative; several fungal skin test and complement fixation test were negative. Repeated chest radiography, lung plaque infiltration persists. Therefore, a high degree of suspicion of allergic reactions caused by metobutidine, is withdrawal, diffuse lung lesions almost completely dissipated within 3 weeks.