High Efficiency Solid Phase Peptide Synthesis (HE-SPPS)

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The recent development of high efficiency solid phase peptide synthesis (HE-SPPS) offers improvements for the assembly of peptides due to its high purity,rapid speed (4 min cycle times),and low chemical usage characteristics [1].Key features of this process are newly developed microwave enhanced reaction conditions,a novel deblocking cocktail,low cost in-situ carbodiimide based activation,optimized washing,and ultra-fast automation.This new process was initially developed on a series of 6 difficult peptides and has met or exceeded the maximum purity observed under any method.
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