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Aim:The aim of the study was to investigate the central mechanism for modulation of chronic intermittent hypobaric hypoxia (CIHH) on baroreflex in renovascular hypertension (RVH) rats.Methods:Male adult Sprague-Dawley rats were randomly divided into four groups:Sham-operated (Sham) group,renovascular hypertension (group,CIHH treatment (CIHH) group,RVH and CIHH treatment (RVH+CIHH)group.Two-kidney-1-clip method was used to make RVH rats.