temozolomide相关论文
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目的探讨替莫唑胺辅助术后序贯放疗和同期放疗治疗星形细胞瘤的临床疗效及安全性。方法选取2008年7月至2012年7月星形细胞瘤患者90......
目的探讨二十碳五烯酸(EPA)对胶质瘤U87细胞替莫唑胺(TMZ)化疗敏感性的影响及其机制。方法胶质瘤U87根据不同药物干预分为：对照组、......
Objective: The aim of our study was to analyze the long-term results of rituximab combined with temozolomide in treatmen......
脑转移性肿瘤是成人最常见的颅内恶性肿瘤，治疗手段有限，传统的治疗方法主要以放射治疗为主。替莫唑胺是新一代的烷化剂，具有透过血脑......
Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozol
Objective:Temozolomide (TMZ) is commonly used for glioblastoma multiforme (GBM) chemotherapy.However,drug resistance lim......
多形性胶质母细胞瘤是中枢神经系统最常见的恶性肿瘤,而且在胶质瘤中恶性程度最高.替莫唑胺为治疗多形性胶质母细胞瘤的新型烷化剂......
目的:研究替莫唑胺联合放疗治疗胶质母细胞瘤的成本-效果。方法:根据临床试验(EORTC26981/22981-NCIC CE3)数据,结合我国医疗费用......
Combination therapy of long-term tumor treating fields with temozolomide and bevacizumab prolongs su
The multifocal glioblastomas (GBM) are tumors with multiple discrete areas of contrast enhancing tumors which have consi......
目的探讨高压氧(HBO)联合替莫唑胺(TMZ)对神经胶质瘤U373MG细胞凋亡的影响及其作用机制。方法U373MG细胞培养完成后分为4组：对照组(......
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Background:The radiochemotherapy regimen concomitantly employing temozolomide (TMZ) chemotherapy and radiotherapy (RT) 4......
Objective:Glioblastoma is the most common primary brain tumor in adults and one of the most lethal human tumors. It cons......
High grade gliomas are always the research focus in the field of neurosurgery due to their poor prognosis despite the cu......
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Objective: The aim of our study was to analyze the long-term results of rituximab combined with temozolomide in treatmen......
Objective: This phase II study aimed at investigating the correlation between O6-methylguanine-DNA methyl-transferase (M......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的 通过体内实验探讨外源性p53上调凋亡调控因子(PUMA)对人类脑胶质瘤细胞生长的影响及其增强胶质瘤细胞对替莫唑胺(TMZ)敏感性......
Objective: This phase II study aimed at investigating the correlation between O6-methylguanine-DNA methyl-transferase (M......
目的 根据肿瘤组织O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)表达的差异选择不同的替莫唑胺(TMZ)方案对恶性胶质瘤进行化疗,评价其客观疗......
目的 探讨难治性垂体腺瘤有效的综合治疗方法.方法 采用手术、伽玛刀及再次手术治疗1例难治性垂体腺瘤患者,然后根据其原代肿瘤细......
替莫唑胺是新一代口服烷化剂,能有效透过血脑屏障,有近100％的生物利用度.替莫唑胺可明显改善恶性胶质瘤患者的预后,与传统化疗药物......
目的 以卡莫司汀(BCNU)为对照,观察替莫唑胺(TMZ)对胶质母细胞瘤化疗的疗效,并探讨O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)的表达对胶......
目的 探讨miR -21过表达在替莫唑胺诱导胶质瘤U87细胞凋亡中的作用及其机制.方法 miR - 21过表达载体转染U87细胞,Hoechst 33258染......
原发性恶性脑肿瘤相对少见,然而却是最致命的癌症之一.胶质母细胞瘤是最常见的恶性胶质瘤,预后最差,对促凋亡的化疗抵抗.目前广泛......
目的 探讨替莫唑胺(TMZ)短期化疗下P57在胶质母细胞瘤细胞增殖抑制中的作用和机制. 方法 通过Western blotting检测P57和核增殖抗......
O6-methylguanine DNA methyltransferase(MGMT) can remove DNA alkylation adducts, thereby repairing damaged DNA and contri......
目的 研究白藜芦醇增强恶性胶质瘤细胞对替莫唑胺(TMZ)药物敏感性的分子机制. 方法 体外常规培养人源性恶性胶质瘤细胞系T98G细胞,......
目的 研究双氢青蒿素(DHA)抑制胶质瘤生长作用、机制及联合替莫唑胺(TMZ)的协同抗肿瘤作用.方法 选用胶质瘤细胞株10个,MTT法检测D......
目的探讨抗抑郁药地昔帕明（DMI）对人脑胶质瘤耐药细胞（U251/TR）对替莫唑胺（TMZ）耐药作用的影响及其机制。方法 DMI 20~80μmol·L-1或TMZ......
