Background: The GGGGCC (G4C2) repeat expansion in the human open reading frame 72 on chromosome 9, C9orf72, is the most ......

利用CRISPR/Cas9基因敲入技术建立稳定表达FUS(fused in sarcoma)的细胞系.方法:扩增FUS 5arm序列,puro-T2A-GFP报告基因,FUS 3arm......

Mdm2 and Mdm4 are two key negative regulators of the tumor suppressor p53.Deletion of either Mdm2 or Mdm4 induces p53-de......