Ubiquitination相关论文
DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating F
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目的观察弥漫大B细胞淋巴瘤（DLBCL）患者小泛素相关修饰蛋白特异性蛋白酶（SENP）1和小泛素相关修饰蛋白（SUMO）1的表达水平，分析其评估预后的......
泛素特异性蛋白酶(USP)在调节蛋白酶体的活性、器官的发生、肿瘤的形成以及转录调控等方面都具有重要的作用.其中,USP9X通过去泛素......
Both plant receptor-like protein kinases (RLKs) and ubiquitin-mediated proteolysis play crucial roles in plant responses......
RING finger protein RGLG1 and RGLG2 negatively modulate MAPKKK18 mediated drought stress tolerance i
Mitogen activated protein kinase kinase kinase 18 (MAPKKK18) mediated signaling cascade plays important roles in Arabido......
Suppression of DRR1 results in the accumulation of insoluble ubiquitinated proteins, which impairs d
Drought stress has detrimental effects on plants. Al-though the abscisic acid (ABA)-mediated drought response is well es......
Meiosis is a specialized cell division for producing haploid gametes in sexually reproducing organisms.In this study,we ......
Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepat
Primary hepatocytes(PHCs)are widely used in various fields,but the progressive deterioration of liver-specific features ......
Tripartite motif(TRIM)family proteins are important effectors of Innate immunity against viral infections.Here we identi......
T cells efficiently respond to foreign antigens to mediate immune responses against infections but are tolerant to self-......
Maintenance of cell junctions plays a crucial role in the regulation of cellular functions including cell proliferation,......
A Plant Lectin Receptor-like Kinase Phosphorylates the Bacterial Effector AvrPtoB to Dampen Its Viru
Plasma membrane-localized receptor-like kinases (RLKs) perceive conserved pathogen-associated molecular pattems (PAMPs) ......
,Two RING-Finger Ubiquitin E3 Ligases Regulate the Degradation of SPX4, An Internal Phosphate Sensor
SPX-domain-containing proteins (SPXs) play an important role in inorganic phosphate (Pi) sensing,signaling,and transport......
Protein abundance and localization at the plasma membrane (PM) shapes plant development and mediates adaptation to chang......
泛素化是一种广泛存在且非常重要的可逆的蛋白质翻译后修饰,在蛋白质的稳定性、活性、细胞内定位以及免疫系统的调控过程中发挥了......
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圆柱瘤基因（CYLD）是一种肿瘤抑制基因，其突变或缺失将会导致圆柱瘤的发生。由其编码的去泛素化酶CYLD蛋白是去泛素化酶家族的成员。CY......
AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucos
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的探讨3-磷酸肌醇依赖性蛋白激酶1(PDK1)发生多聚泛素化修饰的机制。方法免疫共沉淀(COIP)和免疫印迹(WB)分析PDK1的多聚泛素化......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Protein stability regulators screening assay (Pro-SRSA):protein degradation meets the CRISPR-Cas9 li
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
[目的]探讨自噬相关蛋白和泛素相关蛋白的表达对脂质沉积性肌病(lipid storage myopathy,LSM)的影响.[方法]选择2010年1月至2015年......
Abnormal expression of annexin A2 contributes to metastasis and infiltration of cancer cells.To elucidate the cause of a......
宿主免疫细胞和相关的组织细胞能够通过表达病原模式识别受体(pattern recognition receptor,PRR)即Toll样受体(Toll-like recepto......
炎症性疾病是一类极为常见且危害极大的疾病,以中药抗炎来减轻或治疗炎症性疾病在临床上已得到广泛应用,但其分子机制研究尚处于起......
在机体内,有一系列的酶对蛋白质进行翻译后修饰,从而影响蛋白质的功能,其中泛素化修饰就是一种很重要的修饰,其贯穿着几乎所有的细......
Cullin 4A(CUL4A)is an E3 ubiquitin ligase that directly affects DNA repair and cell cycle progression by targeting subst......
Objective To identify ubiquitinated proteins from complex human multiple myeloma (MM) U266 cells,a malignant disorder of......
目的 构建E6AP蛋白结构域突变真核表达载体,并瞬时转染肿瘤细胞,对其生物学功能进行初步检测.方法 以本实验室保存带有myc标签的E6......
Sef(similar expression to fgf genes)作为FGF信号通路中可诱导的拮抗分子相继在斑马鱼,小鼠,和人类中被鉴定出来,并进行了相应的......
IAPs (inhibitors of apoptosis) are a family of proteins containing one or more characteristic BIR domains. These protein......
人类线性泛素链相关蛋白SHARPIN在哺乳动物体内广泛存在,主要分布于大脑、心脏和睾丸等器官细胞的胞质内,可通过线性泛素化调节介......
