目的:构建人源HtrA1L364P转基因小鼠(Mut-hHtrA1L364P小鼠)并对其进行表型分析和致病机理研究伴有皮质下梗死和白质病变的常染色体......

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背景:伴皮质下梗死和白质脑病的常染色体隐性遗传性脑动脉病(cerebral autosomal recessive arteriopathy with subcortical infar......

Background::Homozygous or compound heterozygous mutations in high temperature requirement serine peptidase A1 (n HT......