环丙沙星又称丙氟哌酸,为第三代喹诺酮类药物中抗菌活性最强的一种抗菌药物,临床用于治疗各种细菌性感染疾病。随着应用的广泛,不良反应的报道亦日见增多。现就其少见的严重不良反应简述如下。 神经系统损害 主要症状有眩晕、困倦、烦躁、头痛及舌唇麻木等,一般在用药2小时后出现。该药还可抑制多巴胺受体和抑制脑内抑制性递质r—氨酷酸与受体结合,有潜在性的诱发震颤或癫痫的作用。报道某患者,82岁,因排尿不畅,用环丙沙星常规剂量静滴导致癫痫发作;该患者既往有脑血栓病史8年。另报道2例男性患者,分别80岁和56岁,给予静滴环丙沙星 Ciprofloxacin, also known as propylene norfloxacin, is the third generation of quinolone antibacterial activity of an antimicrobial drugs, clinically used for the treatment of various bacterial infections. With the wide range of applications, the reports of adverse reactions are increasing day by day. Now its rare serious adverse reactions are summarized as follows. The main symptoms of nervous system damage are dizziness, drowsiness, irritability, headache and numbness of the tongue, usually after 2 hours of medication appear. The drug also inhibits dopamine receptors and inhibits the brain inhibitory transmitter r-amino acid and receptor binding, potentially induced tremor or epilepsy. Reported that a patient, 82 years old, due to poor urination, intravenous infusion of ciprofloxacin caused seizures; past history of cerebral thrombosis in patients with 8 years. Another report of 2 cases of male patients, respectively, 80 years and 56 years old, given intravenous ciprofloxacin