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胺碘酮(又名乙胺碘呋酮)为一良好的广谱抗心律失常药,是控制难治性心律失常的较为突出的一种药物。随着临床的广泛应用,其不良反应亦日趋增多,现将其严重毒性反应简述如下。 抑制窦房结和心脏传导系统功能 引起窦性心动过缓(窦缓)、窦房传导阻滞、窦性停搏及各类房室传导阻滞(房室阻滞)。其中以严重窦缓(心率<40次/分以下)和Ⅰ、Ⅱ度房室阻滞最为多见,发生率分别为9.1％和6.05％,窦缓最慢时心率仅达28次/分,且阿托品不能对抗此反应,常为发生窦房阻滞、窦性停搏和室性心律失常之前奏,主要与用药剂量过大有关。老年人因心肌和心脏传导系统有退行性改变者发生率较多。
Amiodarone, also known as amiodarone, is a well-established broad-spectrum antiarrhythmic drug and is a more prominent drug that controls refractory arrhythmias. With the wide range of clinical applications, its adverse reactions are also increasing, now its serious toxicity reactions are summarized as follows. Inhibition of sinus node and cardiac conduction system function caused sinus bradycardia (sinus slow), sinoatrial block, sinus arrest and a variety of atrioventricular block (atrioventricular block). Among them, severe sinus bradycardia (heart rate <40 beats / min) and Ⅰ, Ⅱ degree atrioventricular block were the most common, the incidence rates were 9.1% and 6.05% respectively. The slowest sinus time was only 28 beats / And atropine can not fight this response, often the occurrence of sinoatrial block, sinus arrest and ventricular arrhythmia prelude, mainly with the dose overdose. The elderly due to myocardial and cardiac conduction system degenerative changes were more frequent.