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目的:探讨阿托伐他汀及阿司匹林对冠心病患者C-反应蛋白的影响。方法:冠心病患者109例随机分为Ⅰ组(37例),Ⅱ组(29例),Ⅲ组(43例),分别应用阿托伐他汀、阿司匹林、阿托伐他汀联合阿司匹林治疗,比较3组用药前后C-反应蛋白水平。结果:3组用药后C-反应蛋白水平均较用药前降低(P<0.05),Ⅲ组C-反应蛋白水平降低优于Ⅰ组,Ⅱ组(P<0.01)。结论:阿托伐他汀联合阿司匹林降低C-反应蛋白水平优于单用阿托伐他汀或阿司匹林。
Objective: To investigate the effect of atorvastatin and aspirin on C-reactive protein in patients with coronary heart disease. Methods: 109 patients with coronary heart disease were randomly divided into group Ⅰ (n = 37), group Ⅱ (n = 29) and group Ⅲ (n = 43). Patients were randomly assigned to receive atorvastatin, aspirin and atorvastatin plus aspirin. Group before and after C-reactive protein levels. Results: The levels of C-reactive protein in three groups were significantly lower than those before treatment (P <0.05). The level of C-reactive protein in group Ⅲ was better than that in group Ⅰ and Ⅱ (P <0.01). CONCLUSIONS: Atorvastatin combined with aspirin is superior to c-reactive protein alone in combination with atorvastatin or aspirin alone.