肠源性内毒素血症（ＥＥＭ）是介导单核－巨噬细胞分泌细胞因子和导致多器官功能不全综合征（ｍｕｌｔｉｐｌｅｏｒｇａｎｄｙｓｆｕｎｃｔｉｏｎｓｙｎｄｒｏｍｅ，ＭＯＤＳ）的重要因素。本研究制备了家兔离体及在体肠袢动物模型，观察了肠腔内施压对肠粘膜损伤及肠腔内内毒素转运之影响。实验结果表明：肠粘膜屏障损害的程度与肠道内压及施压时间的关系呈正比，为进一步研究肠腔内内毒素转运及其影响因素提供了一些实验依据 Gut-derived endotoxemia (EEM) is an important factor that mediates monocyte-macrophage cytokine secretion and multiple organ dysfunction syndrome (MODS). In this study, rabbits were prepared in vitro and in vivo intestinal animal model of intestinal mucosal injury and intestine endotoxin transport observed. The experimental results show that: the degree of damage to the intestinal mucosal barrier and the relationship between intestinal pressure and pressure is proportional to the time for the study of intestinal endotoxin transport and its influencing factors provide some experimental evidence