Purpose: To assess the intraocular pressure (IOP) and corneal endothelial chan ges, over a 6-month period, after a single injection of intravitreal triamcinol one (ivTA) in Chinese patients. Methods: A total of 43 eyes of 43 consecutive Ch inese patients with various macular diseases received a single bolus injection o f 4 mg ivTA, of which, 14 eyes with significant cataracts underwent simultaneous phacoemulsification and primary intraocular lens implantation. IOP was measured preoperatively and weekly in the first month, and then monthly until 6 months p ostinjection. Specular microscopy was performed on 24 of the 29 eyes without sim ultaneous cataract surgery, preoperatively and at months 1, 3, and 6. Results: A ll patients completed 6 months of follow-up. Nine out of 43 (20.9%)-eyes had IOP > 21 mmHg. Their mean maximum IOP was 29.2 mmHg (range 23.0-37.0), necess itating the use of 2.0 types of topical antiglaucomatous medications on average. The IOP elevation occurred at a mean of 5.2 weeks (range 1-17)-postinjection. All IOPs returned to normal, without additional antiglaucomatous medications, b y 6 months. There was no statistically significant difference (paired t-test, P < 0.05) in the corneal endothelial cell count and other specular microscopy para meters up to 6 months after the injections. Conclusion: A single 4 mg bolus inje ction of ivTA appeared to have no harmful effects on the corneal endothelium. Iv TA caused transient IOP elevations in 20.9%of Chinese patients, similar to that observed in Caucasians. As the IOP rise can occur as early as 1 week after the injection, early monitoring will help its early detection and prevent optic nerv e damage. Methods: To assess the intraocular pressure (IOP) and corneal endothelial chan ges, over a 6-month period, after a single injection of intravitreal triamcinolone (ivTA) in Chinese patients. Methods: A total of 43 eyes of 43 consecutive Chinese patients with various macular diseases received a single bolus injection of 4 mg ivTA, of which, 14 eyes with significant cataracts underwent simultaneous phacoemulsification and primary intraocular lens implantation. IOP was measured preoperatively and weekly in the first month, and then monthly until 6 months p ostinjection. Specular microscopy was performed on 24 of the 29 eyes without sim ultaneous cataract surgery, preoperatively and at months 1, 3, and 6. Results: A ll patients completed 6 months after follow-up. Nine out of 43 (20.9%) -eyes had IOP> 21 mmHg. Their mean maximum IOP was 29.2 mmHg (range 23.0-37.0), necessating the use of 2.0 types of topical antiglaucomatous medications on average. The IOP dimensions occurred at a mean of 5.2 weeks (range 1-17) -postinjection. All IOPs returned to normal, without additional antiglaucomatous medications, by 6 months. There was no statistically significant difference (paired t-test, P <0.05) in the corneal endothelial cell count and other Conclusion: A single 4 mg bolus injetion of ivTA appeared to have no harmful effects on the corneal endothelium. Iv TA caused transient IOP elevations in 20.9% of Chinese patients, similar to that observed in Caucasians. As the IOP rise can occur as early as 1 week after the injection, early monitoring will help its early detection and prevent optic nerv damage.