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目的:研究利用医院信息系统监测分析药物性肝损伤的特点。方法:从医院信息系统数据库中提取2011年9月20~30日间丙氨酸氨基转移酶、门冬氨酸氨基转移酶、总胆红素、结合胆红素、碱性磷酸酶和γ-谷氨酰转移酶异常的住院患者资料,进行回顾性分析。结果:可能发生药物性肝损伤的有147例,主要分型为肝细胞性肝损伤。涉及11个科室、13类药物,居首位的是抗菌药。结论:本方法可有效挖掘药物性肝损伤发生的信息,使用计算机自动监测预警药品不良反应有着广泛的应用前景。
Objective: To study the use of hospital information system monitoring drug-induced liver injury characteristics. Methods: The alanine aminotransferase, aspartate aminotransferase, total bilirubin, conjugated bilirubin, alkaline phosphatase and γ-aminobutyric acid were extracted from the hospital information system database from September 20 to September 30, Inpatients with abnormal glutamyl transferase data were analyzed retrospectively. Results: There were 147 cases of drug-induced liver injury, the main type of liver cell injury. Involved in 11 departments, 13 types of drugs, topped the list of antibacterial drugs. Conclusion: This method can effectively tap the information of drug-induced liver injury, and has a wide range of application prospects by computer automatically monitoring early-warning adverse drug reactions.