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目的分析丙型肝炎性肝硬化患者血清内脏脂肪素的表达意义。方法收集河北省沧州市中心医院2014年7月~2015年11月117例丙型肝炎性肝硬化患者(肝硬化组,A级41例、B级42例、C级34例)和20例健康对照人员(对照组)为研究对象,测量两组被试人员的血清内脏脂肪素、胰岛素抵抗指数(HOMA-IR)、白介素-6(IL-6)水平。结果肝硬化组及A、B、C三级患者内脏脂肪素水平低于对照组,HOMA-IR和IL-6水平高于对照组,差异有统计学意义(P<0.05)。A、B、C三级患者的内脏脂肪素水平比较,差异无统计学意义(P>0.05),HOMA-IR和IL-6水平比较,差异有统计学意义(P<0.05)。将内脏脂肪素作为应变量,其他生化指标作为自变量,胰岛素r=-0.237、HOMA-IR r=-0.229、IL-6 r=-0.076,内脏脂肪素与胰岛素、HOMA-IR、IL-6无明显相关性(P>0.05)。结论丙型肝炎性肝硬化患者的内脏脂肪素表达水平较低,内脏脂肪素可作为诊断丙型肝炎性肝硬化的指标,但是不能作为判断肝功能严重程度的指标。
Objective To analyze the significance of serum visfatin in patients with hepatitis C cirrhosis. Methods A total of 117 hepatitis C cirrhosis patients (cirrhosis group, 41 cases of grade A, 42 cases of grade B, 34 cases of grade C) and 20 cases of healthy subjects were collected from Cangzhou Central Hospital of Hebei Province from July 2014 to November 2015. The control group (control group) was used as the study object to measure the levels of serum visfatin, insulin resistance index (HOMA-IR) and interleukin-6 (IL-6) in the two groups. Results The levels of visfatin in patients with cirrhosis, A, B and C were lower than those in control group, and the levels of HOMA-IR and IL-6 were higher than those in control group (P <0.05). There were no significant differences in visceral fat levels among patients with grade A, B, and C (P> 0.05). The levels of HOMA-IR and IL-6 were significantly different (P <0.05). The visceral adiponectin was taken as the dependent variable and the other biochemical indexes as the independent variables. Insulin r = -0.237, HOMA-IR r -0.229, IL-6 r -0.076, visfatin and insulin, HOMA-IR and IL-6 No significant correlation (P> 0.05). Conclusion The expression of visfatin is low in patients with hepatitis C cirrhosis. Visfatin can be used as an index to diagnose hepatitis C cirrhosis, but it can not be used as an index to judge the severity of liver function.