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目的探讨噻托溴铵吸入治疗对老年重度支气管哮喘患者肺功能和气道炎性反应的影响。方法选取2013年6月—2015年6月深圳市宝安区中心医院收治的老年重度支气管哮喘患者98例,采用随机数字表法分为对照组和观察组,各49例。对照组患者采用常规治疗,观察组患者在常规治疗基础上加用噻托溴铵粉吸入治疗。比较两组患者临床疗效、肺功能指标及炎性反应指标。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前两组患者用力肺活量(FVC)、峰值呼吸流速(PEF)及第1秒用力呼气容积占预计值百分比(FEV1%)比较,差异无统计学意义(P>0.05);治疗后观察组患者FVC、PEF、FEV1%高于对照组(P<0.05)。治疗前两组患者血清肿瘤坏死因子α(TNF-α)、白介素6(IL-6)水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血清TNF-α、IL-6水平低于对照组(P<0.05)。结论噻托溴铵吸入治疗老年重度支气管哮喘的临床疗效确切,可有效改善患者肺功能,减轻患者气道炎性反应。
Objective To investigate the effects of inhalation of tiotropium on pulmonary function and airway inflammatory response in elderly patients with severe bronchial asthma. Methods A total of 98 elderly patients with severe bronchial asthma who were admitted to Shenzhen Central Hospital from June 2013 to June 2015 were selected and randomly divided into control group and observation group with 49 cases in each group. Patients in the control group were treated with conventional therapy. Patients in the observation group were treated with tiotropium bromide inhalation on the basis of routine treatment. The clinical efficacy, lung function and inflammatory response were compared between the two groups. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). There were no significant differences in FVC, PEF and FEV1% between the two groups before treatment (P> 0.05). After treatment, the observation group Patients with FVC, PEF, FEV1% higher than the control group (P <0.05). The levels of serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the two groups before treatment were not significantly different (P> 0.05) The level was lower than the control group (P <0.05). Conclusion The efficacy of tiotropium inhalation in the treatment of elderly severe bronchial asthma is definite. It can effectively improve lung function and reduce the airway inflammatory response in patients.