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药物的溶解度数据作为考察药物以及药物制剂的基本参数之一,在药物研发以及相关的工业领域有着重要的意义。现有的溶解度测定基本方法主要有平衡法和动态法等,然而这些传统方法在实际应用中会出现费时费力,样品消耗量大,普遍适用性差等缺点。本文报道了一种测定药物溶解度的新方法——空气湿度法,即采用湿度计测定与药物饱和溶液呈平衡的空气的相对湿度,再用物理化学模型计算出药物的溶解度。以NaCl为模型,在20~50℃内采用新方法测定其溶解度,并与重量分析法测定值及文献报道值进行比较。结果表明空气湿度法测得的溶解度值与重量分析法测定值及文献报道值基本一致。此法测定药物溶解度弥补了现有方法存在的局限性,简便易行,结果可靠,对大多数药物普遍适用。
As one of the basic parameters of drug and drug preparation, the drug solubility data is of great significance in drug development and related industrial fields. The existing basic methods of solubility determination are the balance method and the dynamic method. However, these traditional methods have the disadvantages of time-consuming and labor-intensive, large sample consumption and poor general applicability. In this paper, we report a new method to determine the solubility of drugs - air humidity method, which uses the hygrometer to measure the relative humidity of the air equilibrated with the drug-saturated solution. The physicochemical model is then used to calculate the drug solubility. Using NaCl as a model, the solubility was measured by a new method at 20 ~ 50 ℃, and compared with the gravimetric analysis and literature reports. The results show that the measured value of air humidity and gravimetric analysis of the measured values reported in the literature are basically the same. This method to determine the solubility of drugs to make up for the limitations of existing methods, simple and easy, reliable results, universal application of most drugs.