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目的 :探讨循环内皮细胞 ( CEC)、血液流变性在高血压危象形成中的作用及相互关系。方法 :对 2 2例高血压危象患者、 2 8例高血压病患者和 2 2例正常人 ,以 Percoll密度梯度法分离计数 CEC,并测定切变率为 2 3 0 s- 1及 10 s- 1下的全血粘度。结果 :高血压危象组CEC,ηb均显著高于高血压病组 ,同时亦显著高于正常组。相关分析表明 ,高血压危象组及高血压病组中 ,CEC与ηb( 2 3 0 s- 1 )、ηb( 10 s- 1 )呈正相关关系。结论 :CEC增多及血粘度增高是高血压病和高血压危象形成的重要原因。
Objective: To investigate the role and relationship of circulating endothelial cells (CEC) and hemorrheology in the formation of hypertensive crisis. Methods: Twenty-two hypertensive crisis patients, 28 hypertensive patients and 22 normal controls were enrolled. Peripheral blood count (CEC) was measured by Percoll density gradient and the cut rates were determined at 230 s-1 and 10 s - 1 under the whole blood viscosity. Results: The levels of CEC and ηb in hypertensive crisis group were significantly higher than those in hypertension group and significantly higher than those in normal group. Correlation analysis showed that there was a positive correlation between CEC and ηb (230 s-1) and ηb (10 s-1) in hypertensive crisis group and hypertension group. Conclusion: The increase of CEC and the increase of blood viscosity are the important reasons for the formation of hypertension and hypertension crisis.