目的探讨窒息对新生儿肾功能的影响。方法对343例窒息新生儿出生后一周内血尿素氮(BUN)和血肌酐(Scr)的动态检测结果进行分析。结果343例窒息新生儿中发生肾功能损害68例,发生率为19.83%。窒息组生后24～48h血BUN和Scr浓度均高于24h内,P<0.01。窒息组24h内及24～48h血BUN和Scr浓度均高于对照组,P<0.01。轻、重度窒息后肾功能损害发生率分别为19.87%、19.57%,差异无显著意义,P>0.05。两组间肾功能恢复至正常水平的平均时间(轻度组4.6d,重度组6d)比较,各时间段Scr浓度比较,24h内血BUN浓度比较,肾功能损害患儿中低钠血症发生率比较,均无显著差异,P均>0.05。结论窒息新生儿肾功能损害发生率高,发生率与窒息程度无关。对窒息新生儿应常规动态监测血BUN和Scr,可以及时发现肾功能损害。 Objective To investigate the effect of asphyxia on neonatal renal function. Methods The dynamic test results of blood urea nitrogen (BUN) and serum creatinine (Scr) in 343 asphyxiated newborns one week after birth were analyzed. Results Among the 343 asphyxiated newborns, 68 cases had renal dysfunction, the incidence rate was 19.83%. The concentrations of BUN and Scr in blood of asphyxia group were higher than that of 24h group (P <0.01) 24-48 h after birth. The levels of BUN and Scr in blood of asphyxia group were higher than those of control group within 24h and 24-48h (P <0.01). The incidence of renal dysfunction after mild and severe asphyxia were 19.87% and 19.57%, respectively, with no significant difference (P> 0.05). The mean time between the two groups recovering to normal level (mild group 4.6d, severe group 6d), comparing Scr concentration in each time period, blood BUN concentration in 24h, renal dysfunction in children with hyponatremia Rate, no significant difference, P> 0.05. Conclusion The incidence of renal dysfunction in neonates with asphyxia is high, the incidence is not related to the degree of asphyxia. Asphyxia newborns should be routinely dynamic monitoring of blood BUN and Scr, renal damage can be found in time.