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目的目前结直肠癌发病率逐年上升,已经成为危害我国人民健康的常见原因之一。本研究旨在探讨结直肠癌患者临床病理特征及其与预后的关系。方法收集南方医科大学南方医院普通外科2005年1月～2008年9月期间结直肠癌患者情况,进行随访。选择年龄、性别、肿瘤大小、肿瘤大体类型、组织类型、肠壁浸润深度、Dukes分期、是否存在淋巴结转移等8项临床病理指标,用单因素和多因素分析的方法研究其对243例结直肠癌患者预后的影响。结果单因素分析结果显示,年龄、Dukes’分期、是否存在淋巴结转移为影响结直肠癌患者预后的因素。COX比例危险回归模型多因素分析显示,仅年龄及是否存在淋巴结转移结直肠癌患者预后的独立影响因素。结论年龄和是否存在淋巴结转移是结直肠癌患者预后的重要指标。
Objective The current incidence of colorectal cancer has risen year by year and has become one of the common causes that endanger the health of our people. This study aimed to investigate the clinicopathological characteristics of patients with colorectal cancer and its relationship with prognosis. Methods The patients with colorectal cancer in General Surgery, Nanfang Hospital, Southern Medical University from January 2005 to September 2008 were collected and followed up. Eight clinical and pathological parameters such as age, sex, tumor size, gross tumor type, histological type, depth of intestinal wall invasion, Dukes stage and lymph node metastasis were analyzed. One-factor and multivariate analysis were performed on 243 patients with colorectal The prognosis of cancer patients. Results The results of univariate analysis showed that age, Dukes’ stage and lymph node metastasis were the prognostic factors in patients with colorectal cancer. Multivariate analysis of the COX proportional hazards regression model showed that independent factors influencing the prognosis of patients with lymph node metastases only by age and presence or absence. Conclusion Age and presence of lymph node metastasis are important prognostic indicators in patients with colorectal cancer.