目的:评价氟罗沙星治疗下呼吸道感染的临床疗效。方法:57例下呼吸道感染患者随机分为二组。治疗组30例,应用氟罗沙星0.4 g·d-1静滴,平均治疗日8.7±2.6。对照组27例,应用氧氟沙星0.2 g,bid,静滴,平均治疗日9.1±2.5。结果:治疗组及对照组临床有效率分别为90％(25/30),85.18(23/27),细菌清除率分别为92.59％(25/27),88％(22/25)。结论:氟罗沙星是治疗下呼吸道感染安全有效的药物。 Objective: To evaluate the clinical efficacy of fleroxacin in the treatment of lower respiratory tract infection. Methods: 57 cases of lower respiratory tract infection were randomly divided into two groups. In the treatment group, 30 patients were treated with fleroxacin 0.4 g · d-1 intravenously, with an average treatment day of 8.7 ± 2.6. Control group, 27 cases, ofloxacin 0.2 g, bid, intravenous infusion, the average treatment day 9.1 ± 2.5. Results: The clinical effective rates of the treatment group and the control group were 90% (25/30) and 85.18 (23/27), respectively. The bacterial clearance rate was 92.59% (25/27) and 88% (22/25) respectively. Conclusion: Fleroxacin is safe and effective in the treatment of lower respiratory tract infections.