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冠醚化学是近代化学领域里一门非常活跃的学科,随着冠醚的应用范围不断扩大,迫切地要求其合成方法能与之相适应。如果对其合成方法进行有效的改进,是有实际价值的。新型多配位基冠醚的合成,按文献所述,反应时间和纯化时间都很长,溶剂消耗量大,操作复杂,作者在合成这类冠醚化合物的过程中,研究出一种快速简便的管道化方法。本文报道应用这一方法子1,4,7,10-四氧杂环十三烷11,13-二酮(冠醚1)和1,4,7,10,13-五氧杂环十六烷14,16-二酮(冠醚2)的合成。
Crown ether chemistry is a very active discipline in modern chemistry. With the increasing application of crown ether, its synthesis method is urgently required to be compatible with it. If the synthesis method for its effective improvement, there is real value. According to the literature, the synthesis of novel multi-ligand crown ethers has long reaction time and purification time, large solvent consumption and complicated operation. In the process of synthesizing such crown ether compounds, the authors have developed a quick and easy The pipeline method. This paper reports the application of this method to sub-1,4,7,10-tetraoxacyclotridecane 11,13-dione (crown ether 1) and 1,4,7,10,13-pentacyclohexadecane Synthesis of alkyl 14,16-dione (crown ether 2).