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本研究对10只家兔(其中3只为正常组,2只为对照组,5只为迷走神经切断组)进行了实验性观察,其结果如下:1.对照组动物的人造溃疡在择期杀死时均未痊愈,而迷走神经切断组动物的人造溃疡除两例实行胃前迷走神经切断术的动物未痊愈外,其余的均已痊愈。2.在电镜下观察,对照组动物的壁细胞和胃酶细胞与正常组动物的同类细胞相比,没有发生显著的改变。但迷走神经切断组动物与正常组和对照组动物的同类细胞相比,却发生了显著的退行性改变。壁细胞变化特点是,核呈现不同程度的浓缩和深染;细胞内小管的微绒毛变短变粗或萎缩,排列不规则,微绒毛间间隙加大;管囊泡明显扩张和稍显增多;线粒体嵴模糊不清;溶酶体增多;高尔基复合体变形。胃酶细胞变化特点是,核浓缩;酶原颗粒减少或排空;溶酶体增多;粗面内质网轻度扩张,排列紊乱呈网状,其上的核朊粒明显减少;高尔基复合体变形。3.作者在电镜下观察到家兔胃粘膜中存在着不同类型的嗜银细胞,尤以神经切断组动物内为多,其原因有待进一步研究。根据大体标本和电镜观察,本文为迷走神经切断术治疗溃疡病的机理提供了一定的形态学依据。
In this study, 10 rabbits (3 of them were normal group, 2 as control group and 5 as vagotomy group) were observed experimentally and the results were as follows: 1. The artificial animals in control group were killed selectively Were not cured, while the artificial vaginal nerve group cut off the animals in addition to two cases of gastric vagotomy in animals not cured, the rest have been cured. Under electron microscope, there was no significant change in the parietal cells and gastric enzyme cells in the control animals compared with the normal cells in normal animals. However, there was a significant degenerative change in the vagotomized animals compared with the same kind of cells in the normal and control animals. The changes of parietal cells were characterized by different concentrations of condensed and dark stained nuclei. The microvilli of the intraductal cells became shorter or thicker and irregularly arranged, and the gaps between the microvilli increased. The vesicles of the cysts were obviously expanded and slightly enlarged. Mitochondrial ridges blurred; increased lysosomes; deformation of the Golgi complex. Gastric enzyme cell changes are characterized by nuclear condensation; reduction or emptying of zymogen particles; increase in lysosomes; rough endoplasmic reticulum mild dilatation, disordered network reticular, the nuclear prion significantly reduced; Golgi complex Deformation. The authors observed in the electron microscope rabbit gastric mucosa there are different types of argyrophilic cells, especially in the group of neurotomy more animals, the reason remains to be further studied. According to the gross specimen and electron microscope observation, this article provides some morphological evidences for the mechanism of vagotomy for ulcer disease.