我院14年来遇到6例亚急性联合变性(SCD),都曾误诊,现将其中三典型病例报告如下。例1:女,48岁。因双下肢不能站立6个月,于1977年3月18日入院。8个月前始感双下肢远端麻木力弱,1月后下肢活动笨拙,行走不稳,足底有踏棉感,以后则不能站立。医院诊为多发性末稍神经炎,用维生素B_(12)(以下简称B_(12))治疗月余,能行走10余米,中断用药后病情又加重。体检:T36.7,P72,BP13/8kPa,胸腹部无特殊,颅神经无异常,双下肢瘫痪,肌力Ⅲ级,肌张力增高,远端呈袜套式痛,温觉减退,下肢音义振动觉和关节位置觉消失,跟膝胫试验欠稳准,膝及跟腱反射亢进,双侧巴氏征(+), In our hospital for 14 years, 6 cases of subacute combined degeneration (SCD) have been encountered and all of them have been misdiagnosed. Three typical cases are reported as follows. Example 1: Female, 48 years old. Because of the lower limbs can not stand for 6 months, on March 18, 1977 admission. 8 months ago, the beginning of the lower extremity distal numbness weak, lumbar activity in January after clumsiness, walking unsteadily, foot tread cotton feeling, then you can not stand. The hospital was diagnosed as multiple peripheral neuritis. After treatment with vitamin B_ (12) (hereinafter referred to as B_ (12)) for more than 10 months, the disease was aggravated after the drug was discontinued. Physical examination: T36.7, P72, BP13 / 8kPa, no special chest and abdomen, no abnormal cranial nerves, paralysis of both lower extremities, grade Ⅲ muscle strength, increased muscle tone, sock-like pain distal, temperature regained, And joint position feel disappeared, with knee shin test less accurate, knee and Achilles tendon hyperreflexia, bilateral Pakistan’s sign (+),