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据报道,异丙肌苷(inosiplex)具有免疫调节作用:刺激或抑制人 T 细胞,亦可刺激单核细胞,增加人体血液 T 细胞百分率。最近的试验提示,异丙肌苷可引起单纯疱疹、鼻病毒感染、流感、亚急性硬化性全脑炎和病毒性脑炎患者临床和免疫学改善。鉴于类风湿性关节炎(RA)发病机理中可能有病毒触发的免疫机理参与,作者试用本药治疗 RA 患者。对15例典型 RA 患者给予异丙肌甙治疗,每天3g,分3次口服,直至病情改善时剂量减至每天1～2g。若治疗3个月无效则停药。治疗2个月后对15例
It has been reported that inosiplex has an immunomodulatory effect: stimulating or inhibiting human T cells, stimulating monocytes and increasing the percentage of human blood T cells. Recent trials suggest that isoprinos can cause clinical and immunological improvement in patients with herpes simplex, rhinovirus infections, influenza, subacute sclerosing and encephalitis. In view of the possible involvement of virus-triggered immune mechanisms in the pathogenesis of rheumatoid arthritis (RA), the authors tested this drug in patients with RA. 15 cases of typical RA patients given isoposide treatment, 3g daily, 3 times orally, until the condition improved dose reduced to 1 ~ 2g per day. If the treatment is invalid 3 months withdrawal. After 2 months of treatment of 15 cases