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目的观察左旋卡尼汀对慢性缺血性心脏病心力衰竭患者心功能的影响。方法90例慢性心力衰竭患者(NYHA心功能分级Ⅱ～Ⅳ级)随机分为治疗组(45例)和对照组(45例)。对照组给予常规药物治疗,治疗组在常规药物治疗基础上加服左旋卡尼汀,治疗20d。治疗前后行心脏彩色超声检查,评估心功能;同时测定治疗前后的心功能指标:左室射血分数(LVEF)左室收缩末期内径(LVESD)左室舒张末期内径(LVEDD)。结果治疗组心功能明显好转,LVEF、和LVESD较治疗前明显改善,与对照组比较有显著性差异(P<0.05)。结论卡尼汀改善缺血心肌能量代谢,对心功能有保护作用,尤其左心室收缩功能。
Objective To observe the influence of L-carnitine on cardiac function in patients with chronic ischemic heart disease and heart failure. Methods 90 patients with chronic heart failure (NYHA functional class Ⅱ ~ Ⅳ grade) were randomly divided into treatment group (45 cases) and control group (45 cases). Control group was given conventional drug treatment, the treatment group on the basis of conventional drug therapy plus service L-carnitine, treatment 20d. The color Doppler echocardiography was performed before and after the treatment to evaluate the cardiac function. The cardiac function parameters of left ventricular ejection fraction (LVEF), left ventricular end diastolic dimension (LVEDD) and left ventricular end-diastolic dimension (LVEDD) before and after treatment were also measured. Results The cardiac function of the treatment group improved obviously. The LVEF and LVESD were significantly improved compared with those before treatment (P <0.05). Conclusion Carnitine can improve myocardial energy metabolism and protect cardiac function, especially left ventricular systolic function.