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NTG对血管平滑肌有明显的舒张作用,但对气道平滑肌的作用尚缺乏很好的研究.本文综述NTG对气道平滑肌的影响,证实其扩张作用不如β—受体激动药那样明显.严重肺疾患病人血管床减少,余下部份仍扩张.COPD病人的肺血管已高度扩张,对缺氧已无收缩反应,用NTG后PO_2降低反不如健康人明显.由于NTG对支气管有扩张作用,虽然它使HPV的机制丧失和静脉血掺杂增加,但仍可在一定程度上改善肺力学.
NTG has a significant relaxation effect on vascular smooth muscle, but the role of airway smooth muscle is still not well studied.This article reviews the effect of NTG on airway smooth muscle, demonstrating that its dilation effect is not as obvious as that of beta-agonist.Serious pulmonary Vascular disease in patients with reduced, the remaining part of the expansion still.COPD patients have a high degree of pulmonary vascular expansion, hypoxia has no contractile response, decreased with NTG after PO2 anti-obvious than healthy people due to NTG on bronchial expansion, although it The mechanism of HPV loss and venous blood doping increase, but still to some extent, to improve lung mechanics.