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在离体豚鼠右心室乳头肌标本上,应用细胞内固定微电极枝术,观察到有机锗化物(简称 DCG)可明显升高动作电位0相最大上升速率,延长动作电位时程及有效不应期,抑制心肌收缩力。给药15min 后使 APD_(50)和 APD_(90)分别从172±11ms 增加到186±14ms,从217±10ms 增至229±12ms。累积浓度给药发现上述作用呈剂量依赖性。在用高钾除极造成快钠通道失活情况下,用 DCG 可使 Vmax 降低而 Fc 减弱,APA 变化不明显。实验结果提示 DCG 可使正常豚鼠乳头肌细胞兴奋收缩脱耦联,抑制慢反应电位及肌张力。因之,认为本药具有 Ca 拮抗剂的效应。使 APD 和 ERP 延长,这提示本药可能具有抗心律失常作用。
Intracellular immobilization of microelectrode technique on isolated papillary duodenal papillary muscle specimens showed that organo-germanide (DCG) significantly increased the maximum rate of action potential 0 phase, prolonged the action potential duration and effectively Period, inhibit myocardial contractility. The APD_ (50) and APD_ (90) were increased from 172 ± 11 ms to 186 ± 14 ms respectively from 217 ± 10 ms to 229 ± 12 ms after 15 min administration. Cumulative dose administration found that the above effects were dose-dependent. In high potassium depolarization resulting in deactivation of fast sodium channel, DCG can make Vmax decreased Fc decreased, APA change was not obvious. The results suggest that DCG can excite the normal guinea pig papillary muscle cells to excite the contraction, inhibition of slow response potential and muscle tone. Therefore, this drug is considered to have the effect of Ca antagonist. The APD and ERP extended, suggesting that the drug may have anti-arrhythmic effect.