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近年来发现,维A类化合物是一类有效的化学防癌剂.全反式维A酸(TRA)是维A类化合物中的一种,对宫颈上皮内癌(又称宫颈异常增生CIN)有明显疗效.为了维持其抗癌变活性,低降全身用药所引起的毒副作用,本文介绍一种简便的局部用药方法,并通过Ⅰ期临床试用观察疗效和吸收情况.将不同量的TRA在聚乙二醇400等溶剂中形成乳剂,以惰性胶原海绵为支持剂,用Hydrogel Hypan制成的宫颈帽扣于子宫颈上,使药物逐渐释放.为了明确其疗效和它在体内的动力学情况,特设计两种方
In recent years, Victoria A class of compounds is a class of effective chemical anti-cancer agent.Anti-trans retinoic acid (TRA) is one of the Victoria A class compounds, cervical intraepithelial neoplasia (also known as cervical dysplasia CIN) Has obvious curative effect.In order to maintain its anti-cancer activity, reduce the systemic toxicity caused by side effects, this article describes a convenient method of topical administration, and clinical efficacy through Phase Ⅰ clinical observation and absorption of different amounts of TRA in Polyethylene glycol 400 and other solvents to form an emulsion, with an inert collagen sponge as a support agent, made with Hydrogel Hypan cervical cap buckle on the cervix, the gradual release of the drug.In order to clarify its efficacy and its dynamics in the body , Specially designed two parties