研究了21种生药的水提取物对培养血管内皮及平滑肌细胞中一氧化氮(NO)合成的作用。结果发现,黄芪、人参和黄芩的水提取物对大鼠血管平滑肌中NO的合成有诱导作用,但对牛颈动脉内皮细胞中NO的合成没有明显的作用。当黄芪和人参水提取物的浓度超过400μg/ml时,其对血管平滑肌细胞中NO合成的诱导作用呈剂量依赖性。当浓 The effects of 21 crude drug extracts on the synthesis of nitric oxide (NO) in cultured vascular endothelium and smooth muscle cells were studied. The results showed that water extracts of Radix Astragali, Radix Ginseng, and Radix Astragali could induce the synthesis of NO in rat vascular smooth muscle, but had no effect on the synthesis of NO in bovine carotid artery endothelial cells. When the concentration of Astragalus membranaceus and ginseng water extract exceeded 400 μg/ml, its induction of NO synthesis in vascular smooth muscle cells was dose-dependent. When strong