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到目前为止,阿司匹林已应用百年,成为医药史上三大经典药物之一,至今它仍是世界上应用最广泛的解热、镇痛和抗炎药,也是作为比较和评价其他药物的标准制剂。临床上有5%～60%的患者虽常规服用阿司匹林,却不能有效地抑制血小板的活性,这种现象被称为阿司匹林抵抗。阿司匹林属于非甾体类抗炎药,导致这种现象的确切原因还不明确,可能与药物间的相互作用、剂量不足等有关。现就相关问题进行分析。
So far, aspirin has been used for hundreds of years and has become one of the three classic drugs in the history of medicine. Up to now, aspirin is still the most widely used antipyretic, analgesic and anti-inflammatory drug in the world and as a standard formulation for comparing and evaluating other drugs. Clinically, 5% to 60% of patients taking aspirin routinely, but can not effectively inhibit platelet activity, a phenomenon known as aspirin resistance. Aspirin belongs to non-steroidal anti-inflammatory drugs, the exact cause of this phenomenon is not yet clear, and may be related to drug interactions, inadequate dosage and so on. Related issues are now analyzed.