概述一、定义:多毛细胞白血病是一种少见慢性增殖性的疾病。发病多为隐袭性。主要临床表现有贫血、脾肿大、全血细胞减少。在血液、骨髓、淋巴结和脾脏可发现异常的单个核细胞,其胞浆或细胞膜周围有绒毛状突出成为有特征性的毛细胞。二、历史:1923年Ewald首先报道,并提出“白血病性网状内皮细胞增生症”这 Overview First, the definition: Hairy cell leukemia is a rare chronic proliferative diseases. Incidence of mostly implicit. The main clinical manifestations are anemia, splenomegaly, pancytopenia. In the blood, bone marrow, lymph nodes and spleen can be found in abnormal mononuclear cells, the cytoplasm or cell membrane around the villous prominence as a characteristic hair cells. Second, history: Ewald first reported in 1923, and proposed “leukemia reticuloendotheliosis” This