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曾报道人参(Panax ginseng)根提取物具有抑制胆固醇酯转移蛋白(CETP)的作用,本次进一步研究发现提取物还能显著抑制ACAT的活性,根据生物活性指导分离法,从人参毛状根提取物中分离出4种成分。 人参干燥毛状根在丙酮溶液中,室温浸泡3天,提取液经浓缩后,以水和己烷萃取,己烷层经减压浓缩后。以硅胶柱和HPLC分离,并根据抑制ACAT活性,从中得到4种
The Panax ginseng root extract has been reported to have the effect of inhibiting cholesterol ester transfer protein (CETP). This further study found that the extract also significantly inhibited the activity of ACAT, and extracted from the ginseng hairy root according to the biological activity guidance separation method. Four components were isolated. The dried hairy root of ginseng was soaked in acetone solution for 3 days at room temperature. The extract was concentrated and extracted with water and hexane. The hexane layer was concentrated under reduced pressure. Separated by silica gel column and HPLC, and obtained 4 kinds according to the inhibition of ACAT activity