大肠埃希氏菌是临床最常见的病原菌之一 ,属肠杆菌科细菌 ,常见的感染部位为泌尿生殖道、胆道、呼吸道等。近年来其对 β 内酰胺类抗生素的耐药性不断升高 ,细菌对抗生素虽有多种耐药机制 ,但对 β 内酰胺类抗生素 80 %左右的耐药是通过产生 β 内酰胺酶来实现的。β 内酰胺酶 Escherichia coli is one of the most common clinical pathogens, belonging to Enterobacteriaceae. The common infection sites are genitourinary tract, biliary tract and respiratory tract. In recent years, its resistance to β-lactam antibiotics continues to rise, although the bacteria have a variety of antibiotic resistance mechanisms, but about β-lactam antibiotics, about 80% of the resistance is achieved by the production of β-lactamase of. β-lactamase